His acting roles included Danny Tanner on the ABC sitcom Full House (1987–1995) its Netflix sequel Fuller House (2016–2020), and the voice of narrator Ted Mosby on the CBS sitcom How I Met Your Mother (2005–2014).
On January 9, 2022, Saget was staying at the Ritz-Carlton Orlando, Grande Lakes, south of Orlando, Florida, near Williamsburg. He was on a stand-up tour and had performed in Ponte Vedra Beach the previous evening.
On February 15, 2022, Kelly Rizzo, Saget's widow, and her three daughters filed a lawsuit against Orange County's sheriff and the medical examiner's office, demanding that some investigation papers pertaining to the actor's death be kept confidential due to their graphic nature.