She gained recognition for her starring role as Monica Geller on the NBC sitcom Friends, which aired from 1994 to 2004.
She owns the production company Coquette Productions, which was created by Cox and her then-husband David Arquette.
She also worked as a director on her sitcom Cougar Town, the television drama film TalhotBlond (2012), and the black comedy drama film Just Before I Go (2014).
Cox began dating Snow Patrol band member Johnny McDaid in late 2013. The couple announced their engagement in June 2014. Soon afterward they called off the engagement, but they have remained a couple.