He made his acting debut as Jason Ioane on the syndicated action drama series Baywatch: Hawaii (1999–2001)
which was followed by portrayals of Ronon Dex on the Syfy science fiction series Stargate Atlantis (2005–2009),
Khal Drogo in the first two seasons of the HBO fantasy drama series Game of Thrones (2011–2012),
Declan Harp on the Discovery Channel historical drama series Frontier (2016–2018), and Baba Voss on the Apple TV+ science fiction series See (2019–present).
Momoa was featured as the lead of the two lattermost series.