Gillan gained recognition for her work in British film and television, particularly for playing Amy Pond, a primary companion to the Eleventh Doctor in the science fiction series Doctor Who (2010–2013)
Her early film roles include Ally in the thriller film Outcast (2010) and Jane Lockhart in the romantic comedy film Not Another Happy Ending (2013.)
She also worked on the stage while in Britain, appearing in John Osborne's play Inadmissible Evidence (2011) before making her Broadway debut in the play Time to Act (2013).
Gillan's accolades include an Empire Award, a National Television Award, a Teen Choice Award and nominations for a British Academy Scotland Film Award, a Critics' Choice Award and a Saturn Award.
She has been noted for her public image and activism, particularly towards suicide prevention.