She has made multiple appearances in major film franchises, including the Transformers franchise, as well as numerous magazines such as Maxim, Rolling Stone, and FHM.
She is the recipient of several accolades, including two Scream Awards and four Teen Choice Awards.
Fox made her acting debut in the family film Holiday in the Sun (2001), which was followed by numerous supporting roles in film and television, such as the teen musical comedy Confessions of a Teenage Drama Queen (2004), as well as a starring role in the ABC sitcom Hope & Faith (2004–2006).
Her breakout role was as Mikaela Banes in the blockbuster action film Transformers (2007), which she reprised in its sequel Transformers: Revenge of the Fallen (2009).
starred as April O'Neil in the superhero action film Teenage Mutant Ninja Turtles (2014) and its sequel Teenage Mutant Ninja Turtles: Out of the Shadows (2016)
and starred as Reagan Lucas in the fifth and sixth seasons of the Fox sitcom New Girl (2016–2017).