The recipient of various accolades, including an Academy Award, a Golden Globe Award, two Screen Actors Guild Awards, and three Critics' Choice Movie Awards
In 2010, she was named one of Time's 100 most influential people in the world.
She has produced some of the films in which she has starred, including Miss Congeniality 2: Armed and Fabulous (2005) and All About Steve (2009).
She served as an executive producer on the ABC sitcom George Lopez (2002–2007), on which she made numerous appearances.